Rare Disease Biotech Offers Access Ahead of Key Milestone

This late-stage biotech is gearing up for Phase 2 trials with an FDA-designated orphan drug. It's already drawing comparisons to recent billion-dollar exits. Backed by a proven biotech incubator, it's now offering early access to its raise.

Business News Digest

ALAN SUDERMAN
September 03, 2025

AP Business Digest

Here are the AP's top business stories that have moved or are planned to move today. All times U.S. Eastern. For up-to-the minute information on AP's coverage, visit AP Newsroom's Coverage Plan.

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UPCOMING

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GOOGLE-ANTITRUST

DESCRIPTION: What to know about a judge's ruling that will require Google to share data with competitors but won't force it to sell off its Chrome browser.

UPCOMING: By 09/03/2025 2:00 p.m. EDT, Text, Photo

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NEW AND DEVELOPING

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FINANCIAL MARKETS

Wall Street steadies itself as Alphabet pulls tech stocks higher

SUMMARY: Wall Street is steadying as Alphabet and other technology stocks rise. The S&P 500 added 035% Wednesday and was on track to break its two-day losing streak since setting its latest all-time high. The Dow Jones Industrial Average fell 188 points, and the Nasdaq composite rose 1%. Google's parent company was one of the strongest forces lifting the market after avoiding some of the worst-case scenarios in an antitrust case. Also helping to steady Wall Street was the bond market, where yields fell following a weaker-than-expected update on the U.S. job market. A day earlier, climbing yields worldwide raised the pressure on the stock market.

WORDS: 669 - MOVED: 09/03/2025 10:26 a.m. EDT

https://newsroom.ap.org/home/search?query=itemid:77290e080d845f9753590aaf3679ccd4&mediaType=text

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WHATSAPP-SECURITY UPDATE

WhatsApp patches exploit allowing hackers to target Apple users

WORDS: 153 - MOVED: 09/03/2025 10:25 a.m. EDT

https://newsroom.ap.org/home/search?query=itemid:0e5081c3eeb44e47e39ddd38c29a6771&mediaType=text

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US--BOEING-JUSTICE DEPARTMENT

Families of Boeing crash victims to make potential final plea for criminal prosecution

SUMMARY: A federal court hearing getting underway in Texas could be the final chance for families of some Boeing 737 Max crash victims to demand criminal prosecution of the company. U.S. District Chief Judge Reed O'Connor is set to hear arguments Wednesday in Fort Worth on a motion to dismiss a felony conspiracy charge against Boeing. The charge relates to crashes in Indonesia and Ethiopia that killed 346 people less than five months apart. Prosecutors allege Boeing deceived FAA regulators about a flight-control system later implicated in the crashes. Boeing agreed to plead guilty last year but struck a revised agreement with the Justice Department that removes the possibility of a trial.

WORDS: 902 - MOVED: 09/03/2025 10:21 a.m. EDT

https://newsroom.ap.org/home/search?query=itemid:395cb5273f88b0a1bec0ef633719abce&mediaType=text

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US--POWERBALL JACKPOT

A $1.4B Powerball jackpot is up for grabs after 40 drawings without a winner

SUMMARY: An estimated $1.4 billion lottery jackpot will be up for grabs after dozens of drawings without a big winner. The massive Powerball prize is the sixth-largest U.S. lottery jackpot. It's the result of 40 consecutive drawings without anyone matching all of the game's six numbers. The 41st drawing on Wednesday night will be just one fewer than the record set last year. All of that losing stems from Powerball's abysmal odds of 1 in 292.2 million. The $1.4 billion jackpot is for a winner who opts to receive 30 payments over 29 years through an annuity. The game's cash option would pay out an estimated $634.3 million.

WORDS: 192 - MOVED: 09/03/2025 10:16 a.m. EDT

https://newsroom.ap.org/home/search?query=itemid:04433409fcf927590fbec599d806e252&mediaType=text

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US-TRUMP-CRYPTO

Trump-backed bitcoin company begins trading on Nasdaq

SUMMARY: A bitcoin treasury and mining company linked to the Trump family has begun trading on the Nasdaq stock market. American Bitcoin's listing follows a merger with Gryphon Digital Mining. The company is backed by Donald Trump Jr. and Eric Trump. Eric Trump, a co-founder, calls the Nasdaq debut a historic milestone for bitcoin in U.S. capital markets. Public companies accumulating bitcoin as a corporate treasury has become a popular trend. American Bitcoin plans to use self-mining operations and opportunistic bitcoin purchases to stand out. The Trump family has shifted from real estate into crypto, launching several projects.

WORDS: 272 - MOVED: 09/03/2025 10:14 a.m. EDT

https://newsroom.ap.org/home/search?query=itemid:69fc9161fe037822e76b02c05f88a5df&mediaType=text

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CB--JAMAICA-ELECTION

Jamaica holds general election as island shaken by corruption, inequity and economic concerns

SUMMARY: Jamaica is holding a general election that many believe could be a defining moment for an island shaken by corruption, inequity and economic concerns. Prime Minister Andrew Holness of the Jamaica Labor Party is seeking a third term in Wednesday's vote. Holness is running against attorney and longtime People's National Party leader Mark Golding. The Jamaica Progressive Party and the United Independents' Congress are also in the running. Nine independent candidates are also registered to contest the election in various constituencies. A total of 63 seats were up for grabs in Jamaica's House of Representatives on Wednesday.

WORDS: 807 - MOVED: 09/03/2025 10:12 a.m. EDT

https://newsroom.ap.org/home/search?query=itemid:66ff9dd2eb8464b7f6a63f684e2189cd&mediaType=text

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US-JOB-OPENINGS

US job openings slip to 7.2 million in July, more evidence the American labor market is cooling

SUMMARY: U.S. employers posted 7.2 million job vacancies in July as the American labor market continued to cool. The Labor Department reported Wednesday that job openings were down from 7.4 million in June and came in modestly below what economists had forecast.The Job Openings and Labor Turnover Survey (JOLTS) showed that layoffs rose. The number of Americans quitting their jobs -- a sign of confidence in their ability to find better pay, opportunities or working conditions elsewhere -- was almost unchanged at 3.2 million from June.

WORDS: 347 - MOVED: 09/03/2025 10:09 a.m. EDT

https://newsroom.ap.org/home/search?query=itemid:f3dbebb204378f8119ad277b1916a7fc&mediaType=text

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US--WPLACE-DRAWING MAP

Welcome to wplace: A chaotic, collaborative digital canvas where users 'paint the world'

SUMMARY: A new online platform called wplace invites users to "paint the world" on a massive digital canvas. This ever-evolving map allows people to create art using a limited number of pixels over time. Many team up to produce larger and more elaborate images. Users have painted tributes to pop culture and symbols of local identity, as well messages of protest and global conflicts. Experts say this reflects an ongoing desire for collaboration and expression in digital spaces. However wplace also faces challenges with content moderation. Some have raised concerns about hate speech, as well as frustrations about others "griefing" their artwork.

WORDS: 1308 - MOVED: 09/03/2025 9:50 a.m. EDT

https://newsroom.ap.org/home/search?query=itemid:345b5ca144417050ab5c455fa984643d&mediaType=text

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CB--CARIBBEAN-US-VENEZUELA

Trinidad and Tobago leader praises strike and says US should kill all drug traffickers 'violently'

SUMMARY: Trinidad and Tobago's prime minister is praising a U.S. strike on a boat suspected of carrying drugs in the southern Caribbean. U.S. President Donald Trump said Tuesday that 11 people were killed aboard the boat that had departed Venezuela which is located near Trinidad and Tobago. Kamla Persad-Bissessar said late Tuesday that the pain and suffering cartels have inflicted on Trinidad and Tobago "is immense." She said that the U.S. military should kill all traffickers "violently." U.S. Secretary of State Marco Rubio said the drugs aboard the vessel were likely headed to Trinidad or elsewhere in the Caribbean.

WORDS: 403 - MOVED: 09/03/2025 9:44 a.m. EDT

https://newsroom.ap.org/home/search?query=itemid:f0529291209ffbf4162340df7860ba4c&mediaType=text

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US--CLIMATE CHOICES-PHANTOM ENERGY

What is phantom energy? The hidden electricity drain explained

WORDS: 800 - MOVED: 09/03/2025 9:00 a.m. EDT

https://newsroom.ap.org/home/search?query=itemid:534aba8eb6866e8244204b6362f37daa&mediaType=text

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EU--CZECH-GERMANY-TANKS

Czechs agree to buy 44 Leopard tanks from Germany in a $1.6 billion deal

WORDS: 153 - MOVED: 09/03/2025 8:13 a.m. EDT

https://newsroom.ap.org/home/search?query=itemid:f3ed86b998653a82d01f04cdf8dfc2ed&mediaType=text

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MACY'S-RESULTS

Macy's quarterly profit and sales fall but it raises guidance with those declines limited

SUMMARY: Macy's reported lower profits and sales during the fiscal second quarter as the department store chain grapples with a still cautious consumer and higher costs from President Donald Trump's tariffs. But the results, announced Wednesday, beat Wall Street expectations and the department store chain, which operates Bloomingdale's, cosmetics chain Bluemercury and its namesake stores, posted a surprise increase in comparable sales-- those from established stores and online channels. Macy's said the figure marked the best performance for comparable sales in 12 quarters, underscoring that its efforts to improve customer service and merchandise are helping to get shoppers to spend. The company also boosted its financial outlook, though it said it still remains cautious for the year.

WORDS: 385 - MOVED: 09/03/2025 8:02 a.m. EDT

https://newsroom.ap.org/home/search?query=itemid:1b620a3c1fcb062d285960a34e87f351&mediaType=text

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BEHIND THE WHEEL-PASSPORT VS 4RUNNER

Edmunds SUV comparison: New Honda Passport vs Toyota 4Runner

SUMMARY: The redesigned 2026 Honda Passport brings boxier styling, new features and more interior space to the automaker's midsize SUV. It's also suitable for some family adventure to go with its focus on comfort, offering two off-road-capable TrailSport trim levels. The Toyota 4Runner, meanwhile, has a hard-earned reputation for off-road capability, and its overhaul for the 2025 model year reinvigorated it with new styling, the latest technology features, and an available hybrid powertrain that promises increased performance without sacrificing mpg. Which one is the better buy for you? Edmunds' experts put them to test to find out.

WORDS: 883 - MOVED: 09/03/2025 6:43 a.m. EDT

https://newsroom.ap.org/home/search?query=itemid:a4d752402ddd445bb6445fd1a9df017c&mediaType=text

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EU--CZECH-TOYOTA

Toyota announces $792m expansion of Czech plant to build new electric car

WORDS: 149 - MOVED: 09/03/2025 5:32 a.m. EDT

https://newsroom.ap.org/home/search?query=itemid:d652217bf5559aa816236ea8c1338a63&mediaType=text

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AS--JAPAN-SUNTORY-RESIGNATION

Chief of Japanese beverage giant Suntory claims innocence after resigning over CBD supplement

SUMMARY: The former chief executive of Japanese beverage giant Suntory has acknowledged he was investigated on suspicion of possessing an illegal drug but has asserted his innocence despite resigning from his position. Takeshi Niinami told reporters Wednesday he has not broken the law. Police confirmed Niinami was under investigation without giving further details. Niinami says the case involves a CBD supplement made in the U.S. and sent to him by a friend who recommended it for jet lag. Niinami says he assumed the supplement was legal. Niinami oversaw a 2014 Suntory acquisition of Beam Inc. for $16 billion that included iconic brands such as Jim Beam Bourbon and Sauza Tequila.

WORDS: 357 - MOVED: 09/03/2025 5:23 a.m. EDT

https://newsroom.ap.org/home/search?query=itemid:e4531e629bebbf4875f0f6d631ef7e72&mediaType=text

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US--TRUMP-HEALTH-MEDIA

US media quickly forced to revisit a thorny question: How should a president's health be covered?

SUMMARY: At President Donald Trump's news conference, Fox News' Peter Doocy asked something that surely baffled those who avoided social media over Labor Day: "How did you find out over the weekend that you were dead?" Doocy referred to questions about Trump's health that swirled through social media over the weekend. With a 50-minute appearance, Trump certainly put to rest rumors that he was dead or seriously ill. But for the news media, it quickly renewed questions about whether they were being diligent enough in investigating questions over a president's health -- a year after they dealt with the same issues with Joe Biden.

WORDS: 976 - MOVED: 09/03/2025 12:01 a.m. EDT

https://newsroom.ap.org/home/search?query=itemid:1541184240d9092f08159fa36a05a955&mediaType=text

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